Working unsocial hours was found to increase the chances of a heart attack by more than a fifth, with the risk of a stroke rising by 5%.
But experts have disagreed about their association with heart and artery disease.
The new research, the largest analysis of shift work and heart risk to date, pulled together evidence from 34 studies involving more than two million people.
The chances of "any coronary event" were increased by 24%, and of heart attacks by 23%, while stroke risk was raised slightly by 5%.
Despite the relatively small effect, the impact on a large population could be significant, the authors pointed out.
Shift work is associated with vascular events, which may have implications for public policy and occupational medicine.– Dr Daniel Hackam, from Western University in Canada
Night shifts were associated with the steepest increase in risk for coronary events, 41%. But research found no link between shift work and higher death rates from any cause.
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