What is hepatitis C?
Hepatitis C is an infection with the hepatitis C virus. Although
there is no vaccine to protect against infection, there is effective
treatment available.
Estimates suggest over 250,000 people in the
UK have been infected with hepatitis C, but eight out of 10 don’t know
they have it because they have no symptoms. About 75% of these people go
on to develop a chronic hepatitis.
Because it can take years,
even decades, for symptoms to appear, many people (possibly 100,000 or
more) remain unaware they have a problem. By the time they become ill
and seek help, considerable damage has been done to the liver. This
might have been prevented if the person had been diagnosed earlier.
Elsewhere
in the world, hepatitis C is even more common – the World Health
Organization estimates that three per cent of the world’s population
(about 170 million people) have chronic hepatitis C and up to four
million people are newly infected each year.
Hepatitis C symptoms
In most cases, the initial infection doesn't cause any symptoms. When it does, they tend to be vague and non-specific.
Possible symptoms of hepatitis C infection include:
- Fatigue
- Weight loss
- Loss of appetite
- Joint pains
- Nausea
- Flu-like symptoms (fever, headaches, sweats)
- Anxiety
- Difficulty concentrating
- Alcohol intolerance and pain in the liver area
The most common symptom experienced is fatigue, which may be mild
but is sometimes extreme. Many people initially diagnosed with chronic fatigue syndrome are later found to have hepatitis C.
Unlike hepatitis A and B, hepatitis C doesn't usually cause people to develop jaundice.
About
20-30 per cent of people clear the virus from their bodies - but in
about 75 per cent of cases, the infection lasts for more than six months
(chronic hepatitis C). In these cases, the immune system has been
unable to clear the virus and will remain in the body long term unless
medical treatment is given. Most of these people have a mild form of the
disease with intermittent symptoms of fatigue or no symptoms at all.
About
one in five people with chronic hepatitis C develops cirrhosis of the
liver within 20 years (some experts believe that, with time, everyone
with chronic hepatitis C would develop cirrhosis but this could take many decades).
Hepatitis C causes
Hepatitis C virus is usually transmitted through blood-to-blood
contact. One common route is through sharing needles when injecting
recreational drugs - nearly 40 per cent of intravenous drug users have
the infection and around 35 per cent of people with the virus will have
contracted it this way.
Similarly, having a tattoo or body piercing with equipment that has not been properly sterilised can lead to infection.
Before
1991, blood transfusions were a common route of infection. However,
since then all blood used in the UK has been screened for the virus and
is only used if not present.
Hepatitis C can be sexually
transmitted, but this is thought to be uncommon. It can be passed on
through sharing toothbrushes and razors. It is not passed on by everyday
contact such as kissing, hugging, and holding hands - you can't catch
hepatitis C from toilet seats either.
If someone needs a blood
transfusion or medical treatment while staying in a country where blood
screening for hepatitis C is not routine, or where medical equipment is
reused but not adequately sterilised, the virus may be transmitted.
Most
people diagnosed with hepatitis C can identify at least one possible
factor which may have put them at risk but for some, the likely origin
of the infection isn't clear. Because it can remain hidden and
symptomless for so many years, it may be very difficult to think back
through the decades to how it might have begun.
Preventing hepatitis C
There are a number of ways to reduce the risk of the infection being
transmitted. Those most at risk of contracting the infection are
injecting drug users, who should never share needles or other equipment.
Practising safe sex by using condoms is also important.
People with hepatitis C infection aren't allowed to register as an organ or blood donor.
Hepatitis C test
If you think you could have been in contact with the hepatitis C
virus at any point in the past, you can have a test to find out if
you've been infected. You should ask you GP. Local drug agencies and
sexual health clinics (sometimes called genito-urinary medicine or GUM
clinics) may also offer testing.
Hepatitis C treatments
People with chronic hepatitis C infection should be seen by a
hospital liver specialist who may recommend antiviral drug treatments
either as single drug therapy or as combination therapy.
Whether
treatment is needed, and if so which type, depends on a number of
factors. These include blood tests to identify which strain of hepatitis
C infection is present and how well the liver is functioning, and a
liver biopsy to establish whether cirrhosis is occurring.
Hepatitis
C can be treated with pegylated interferon alpha and ribavirin. These
drugs help the body's immune system to overcome the virus, and are often
used together as dual or combination therapy which has been shown to be
effective in 55 per cent of cases. Some strains or genotypes of the
hepatitis C virus are more likely to respond than others. Even if the
virus isn't completely cleared, the treatments can reduce inflammation
and scarring of the liver. They may, however, cause side effects that
some people find difficult to tolerate.
A number of new drugs, known as direct acting antivirals or DAAs,
are being developed which work in a different way, by targetting the
virus itself. Two of the drugs, which are types of a group known as
protease inhibitors that block vital enzymes that the hepatitis C virus
needs to reproduce, are now approved for use in Hepatitis C. They may
help to clear the virus from the body when used in combination with the
standard treatments, pegylated interferon alpha and ribavirin.
Many people also find that complementary and lifestyle approaches
help. There is little evidence these can reduce levels of the virus, but
they may help to deal with symptoms and improve quality of life.
READMORE:
http://www.bbc.co.uk/health/physical_health